Discussion Day

Last Update on April. 19, 2007

Half Day Discussions on Fundamentals and on Bio-imaging - Thursday

AIM: To provide a forum for deep and extensive discussion of two major areas of concern for SIMS.

BACKGROUND: The Discussion day program was started at SIMS XV held in Manchester, and succeeded in provoking a deep scientific discussion on a major area concerning SIMS in the style of the “Faraday Discussions”. The SIMS XVI Organizing Committee also concluded that an in-depth scientific discussion focused on major issues in SIMS will be very useful in stimulating advances in SIMS and related techniques. Therefore we have planned a “Discussion Day” consisting of two major themes: Fundamentals and Bio-imaging.

SESSIONS: The Discussion day will consist of two sessions, morning and afternoon. The morning session (Session 1) will be a discussion on two fundamental topics: ionization phenomena and cluster ion impact. This session is planned to be a single session, in order to encourage all of the participants to attend the session, because Fundamentals is the focused theme of this conference. Despite over 40 years of study, there is still much that is not quantitatively understood about the processes that result in ionization of sputtered atoms (and molecules) and part of session 1 will address recent developments in this area. The remainder of session 1 will address cluster ion impact, which holds out great promise for improvements in biomaterials analysis, in particular bioimaging, and for depth profiling of organic, and even inorganic, materials. Although several cluster types and sizes have already been explored the range of cluster sizes is essentially unlimited, and the physics of the impact desorption, and associated ionization, processes can change significantly with cluster size and impact energy.

The afternoon session (Session 2) will be a discussion on Bio-imaging including Bioanalysis and imaging techniques using not only SIMS but also related techniques such as MALDI. As we saw at SIMS XV biological analysis by SIMS has been greatly encouraged over the last decade by a number of advances in instrumentation and analytical protocols. At the same time, parallel advances are being made in related technologies. MALDI imaging has shown some remarkable data and DESI and its variants have been shown to be able to provide images of materials under atmospheric conditions. There is much therefore that is exciting and new in the area. However, despite the positive developments, in most of the publications in these areas there are profound issues that seem frequently to be ignored. This session will examine the issues of these Bioanalysis techniques head-on.

Each session will consist of a keynote lecture, paper presentations and panel discussions. The papers to be discussed will be available for download on the web-site beginning in September. It will be assumed that the papers have been read before the Conference.

The detailed program will be published in April, 2007.

9:00 to 13:00 Session 1 - Discussion on Fundamentals
Chair: Professor Peter Williams, Arizona State University.
Keynote speakers: Professor Kenzo Hiraoka, Yamanashi University
Professor Andreas Wucher, Essen University.

14:00 to 18:00 Session 2 - Discussion on Bio-imaging
Chair: Professor John Vickerman, University of Manchester
Keynote speaker: Professor Steve Boxer, Stanford University.

Session 2 Program